Reviews

RNA-targeted therapeutics

Crooke ST, Witztum JL, Bennett CF, Baker BF · Cell Metabolism, 2018

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Cell Metabolism2018Reviews

Crooke ST, Witztum JL, Bennett CF, Baker BF

A broad review of drugging RNA rather than protein. It brings together antisense oligonucleotides, siRNA and related approaches, explaining the shared logic of recognising a target sequence and the pharmacology, safety and delivery challenges common to all of them. A good single reference for the RNA targeted drug landscape.

Source

Cell Metabolism, 2018. DOI: 10.1016/j.cmet.2018.03.004

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