Chemistry

The medicinal chemistry of therapeutic oligonucleotides

Wan WB, Seth PP · Journal of Medicinal Chemistry, 2016

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Journal of Medicinal Chemistry2016Chemistry

Wan WB, Seth PP

A detailed survey of the chemical modifications that turn a fragile strand into a medicine. It compares backbone changes, two prime sugar modifications, bicyclic nucleic acids and conjugation strategies, and explains how each affects stability, affinity, potency and safety. An essential reference for designing the modification pattern of an oligonucleotide.

Source

Journal of Medicinal Chemistry, 2016. DOI: 10.1021/acs.jmedchem.6b00551

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