Reviews

The current state and future directions of RNAi-based therapeutics

Setten RL, Rossi JJ, Han S · Nature Reviews Drug Discovery, 2019

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Nature Reviews Drug Discovery2019Reviews

Setten RL, Rossi JJ, Han S

A comprehensive review of RNA interference as a drug class, written as the first siRNA medicines reached the clinic. It covers design, chemical modification, delivery beyond the liver and the clinical pipeline, giving a clear map of where the field stood and the problems still to solve. A useful orientation for anyone entering siRNA drug development.

Source

Nature Reviews Drug Discovery, 2019. DOI: 10.1038/s41573-019-0017-4

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