RNA interference

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC · Nature, 1998

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Nature1998RNA interference

Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC

The paper that discovered RNA interference. Fire and Mello showed that double stranded RNA, not single strands, is the potent trigger that silences a matching gene in the worm C. elegans. The work revealed a natural gene silencing pathway, earned the 2006 Nobel Prize in Physiology or Medicine, and laid the foundation for every siRNA medicine that followed.

Source

Nature, 1998. DOI: 10.1038/35888

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