RNA interference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T · Nature, 2001

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Nature2001RNA interference

Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T

The study that made RNA interference usable in human cells. Long double stranded RNA triggers a toxic immune response in mammalian cells, but this work showed that short 21 nucleotide duplexes silence a target gene cleanly without setting off that alarm. It defined the size and shape of the modern synthetic siRNA and opened the door to human therapeutics.

Source

Nature, 2001. DOI: 10.1038/35078107

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