Antisense
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
Bennett CF, Swayze EE · Annual Review of Pharmacology and Toxicology, 2010
Annual Review of Pharmacology and Toxicology2010Antisense
Bennett CF, Swayze EE
A foundational review of how antisense oligonucleotides work as medicines. It lays out the mechanisms by which an ASO can silence, block or reshape a target RNA, the chemistries that make them stable enough to use, and the pharmacology of the platform. It remains a standard starting point for understanding the ASO field.
Source
Annual Review of Pharmacology and Toxicology, 2010. DOI: 10.1146/annurev.pharmtox.010909.105654
Read the paperRelated in the Knowledge Hub
From theory to a synthesis ready oligo
Discovery AI designs, screens and orders custom oligonucleotides in one guided workflow. Talk to our team or start designing today.
One Platform. Three Connected Pillars.