Deoxynucleoside phosphoramidites — a new class of key intermediates for deoxypolynucleotide synthesis

The chemistry that lets any oligonucleotide be made to order. Beaucage and Caruthers introduced the phosphoramidite method, a fast and reliable way to build DNA one base at a time on a solid support. It became the universal standard for oligonucleotide synthesis and underpins every custom oligo ordered today, including those made by Syngenis.