A guide to oligonucleotide chemistry
What oligonucleotides are, how DNA and RNA are built from nucleotides, and why the phosphodiester backbone matters for the medicines being designed on Discovery AI.
8 min read
Read guideGuides
Long form guides to nucleic acid science.
Explainers on the chemistry, design and application of RNA and DNA, written by our chemists for researchers and the next generation of RNA innovators.
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Explainers from our chemists
Antisense oligonucleotides explained
How antisense oligonucleotides silence or reshape a gene's message, the difference between gapmers and splice switchers, and the chemistry that makes them work in patients.
9 min read
Read guidesiRNA design principles
How small interfering RNAs use the cell's own RNA interference machinery, what makes one siRNA more potent and specific than another, and how GalNAc delivery reaches the liver.
10 min read
Read guideChemical modifications: a field guide
The modifications that turn a fragile strand into a medicine: phosphorothioate backbones, two prime sugar chemistries, locked nucleic acids and morpholinos, and when to reach for each.
11 min read
Read guideFrom design to delivered oligo
What actually happens between ordering an oligo and receiving it: solid phase synthesis, scale and yield, purification choices, and the quality control that proves you got what you ordered.
7 min read
Read guidePut it into practice
Design your candidate on Discovery AI
Take these principles from theory to a synthesis ready oligo in one guided workflow.
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